PCQ Product Information for Veterinarians

PCQ Pet™ Product Information for Veterinarians

Veterinarian Accounts

PCQ Pet has been successfully adopted and integrated into advanced and integrative veterinarian practices. 

Contact us to open a veterinarian account, including special veterinarian pricing, samples and technical support from our medical team.

“PCQ Pet is a reliable anti-inflammatory product for my patients with a remarkable safety profile. The calming effect in anxious dogs makes everything else easier for the owner…”

-Tiffany Margolin, DVM

 

The Development of PCQ

PCQ Pet and PCQ Gold (for human use) was developed and patented after extensive research by Professor Suzanne Talcott, PhD; Ariela Thomas, PhD; Geoff Pfeifer, PhD; and Blake Ebersole at a major university. The research focused on the underlying cellular mechanisms and pathways of inflammation, pain and allergies: Interleukin-1a (IL-1a), PPAR-a, TNF-a, etc. Numerous compounds, both natural and drugs were tested for synergy with each other in these cellular models. After two years of work the PCQ combination was discovered. PCQ Pet™ was clinically studied by veterinarians Brian Saunders, DVM, PhD, at a major University Clinic, and used by veterinarians in clinical practice as their front line, natural anti-inflammatory choice for pain and allergies. A patent was issued as a result of demonstrating beneficial anti-inflammatory synergy between PEA, Curcumin and Quercetin.

"Previously, we demonstrated that PCQ Pet, containing PEA, curcuminoids and quercetin, are able to mitigate oxidative stress by reducing ROS and NO production, as well as to downregulate expression of inflammatory markers such as Cox-2, iNOS and TNF-α in RAW264.7 macrophages. Most importantly, a synergistic interaction was demonstrated between PEA and quercetin and PEA and curcuminoids in downregulation of IL-1b mRNA expression. Synergy parameters such as the combination index (CI), dose reduction index (DRI) and isobolograms for two different experimental designs were presented and indicated stronger synergy for the PEA and quercetin combination. These results provide evidence and rationale for the use of these ingredients in association in nutraceutical formulations targeting prevention and treatment of chronic inflammation and pain.”

-Professor Dr Suzanne Talcott

Developed by nutrition scientists in collaboration with university researchers and veterinarians, PCQ Pet directly impacts the major inflammatory pathways associated with some of the most frequent inflammation and age-related health conditions in dogs. PCQ Pet is well established to provide nutritional support to address joint and muscle, skin and gastrointestinal conditions related to uncontrolled inflammation.

PCQ Efficacy

In clinical research at the Texas A&M University College of Veterinary Medicine, PCQ Pet was shown to reduce joint inflammation and increase mobility in older companion dogs. This important research also found dogs who consumed PCQ Pet experienced significant improvements in pain severity, pain interference, and quality of life during middle and older ages. 

In the clinical study, older dogs taking PCQ Pet™ experienced the following:

1. 58% reduction in pain interference
2. 57% improvement in quality of life
3. 32% reduction in pain severity

Numerous canine and human clinical studies have been published on the individual ingredients in PCQ Pet. Please visit our Scientific References page for a partial list of studies on the ingredients in PCQ Pet. 

“In this study, a formulation using PEA, curcuminoids and quercetin, (PCQ PetTM) was developed and tested in a pilot study with family-owned osteoarthritic dogs. For the first time, PEA in combination with polyphenols was investigated as a potential treatment for osteoarthritis (OA) in dogs. Results indicated that an 8-week supplementation with PCQ PetTM exerted beneficial effects, demonstrated by improvement in pain scores and gait, overall quality of life and also positively affecting pro-inflammatory markers in some dogs.”

     - Professor Dr Suzanne Talcott

 

PCQ Pet Product Facts

PCQ Dosage and Administration

PCQ Pet is most effective when taken once daily by mouth, with food, for at least 1-2 weeks. Ideally, a loading dose consisting of double-dosing for the first week will help facilitate results.

PCQ Pet is an easy-to-administer powder. Simply mix the amount listed on the label dosage chart with your dog's favorite food. 

Please review the product label for complete product and dosage information. 

PCQ Safety

PCQ Pet also offers a superior safety and tolerability profile compared to pharmaceutical alternatives.

All three ingredients in PCQ (Palmitoylethanolamide, Curcumin from Turmeric root, and Quercetin) are bioactive compounds found in our food supply, subject to more than 5,000 biomedical studies combined.
 

PCQ Mechanism of Action

PCQ Pet contains a combination of three ingredients combined in a particular ratio, which exhibits strong synergistic activity on key cytokines.

In original, research conducted at Texas A&M, mRNA expression of II-1b, Cox-2, TNF-α was lowered in activated macrophages treated with increasing concentrations of PEA, curcuminoids extract from turmeric, and quercetin (as PCQ Pet). This combination effect was exponentially greater than the same concentration of any two of the individual compounds. 

Please visit our Science page for more information. 

Veterinarian Accounts

PCQ Pet has been successfully adopted and integrated into advanced and integrative veterinarian practices. 

Contact us to open a veterinarian account, including special veterinarian pricing, samples and technical support from our medical team.

Additional Information

PCQ Gold as an Activator of AMPK and Inhibitor of mTOR – A Rapamycin Alternative?

Interested in Healthy aging, Anti-Aging, Longevity science and Biohacking?

PQC Gold is a patented, first-of-its-kind nutritional supplement developed in conjunction with researchers at Texas A&M. It combines the proven synergistic effects of Palmitoylethanolamide (PEA), Curcumin, and Quercetin - as protected by patent for their ability to regulate inflammation mediators like IL-1 alpha and TNF-alpha.

This unique, research-backed synergistic formulation acts as a multi-pathway modulator, engaging cellular targets like AMPK, mTOR, PPARs, and the endocannabinoid system to support healthy metabolism, controlled inflammation response, neurological and emotional balance, and enhanced cellular rejuvenation.

By stimulating AMPK, PQC Gold optimizes energy utilization and metabolic homeostasis. Its ability to modulate mTOR further supports protein synthesis and cellular recycling. Together, these pathways deliver powerful anti-aging benefits at the cellular level. AMPK activation can lead to various cellular and metabolic effects, such as increased glucose and fatty acid uptake, improved insulin sensitivity, and regulation of energy expenditure and mitochondrial function. The mTOR pathway is a crucial signaling pathway that regulates various cellular processes, including cell growth, proliferation, metabolism, and survival. Inhibition of the mTOR pathway can have potential therapeutic benefits in conditions such as cancer, neurodegeneration, and metabolic disorders.

But PQC Gold doesn't stop there. The potent synergistic anti-inflammatory properties of PEA, Curcumin and Quercetin work synergistically to calm oxidative stress, stabilize mast cells, inhibit histamine release, and regulate overactive immune responses through complementary modes of action. Quercetin enhances curcumin's bioavailability while also contributing its own antioxidant effects.

With this groundbreaking combination of synergistic natural compounds, PQC Gold represents the cutting-edge of nutritional supplementation. It's the ideal complement to a healthy lifestyle, providing multi-pathway, multi-target support for vitality, youthful cellular function, metabolic optimization, and systemic inflammatory homeostasis from the inside out.

ABOUT PEA (Palmitoylethanolamide) 

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, and lipid modulator.

A main target of PEA is proposed to be the peroxisome proliferator-activated receptor alpha (PPAR-α). PEA also has affinity to cannabinoid-like G-coupled receptors GPR55 and GPR119, which are under consideration for being included in the endocannabinoid system. PEA cannot strictly be considered a classic endocannabinoid because it lacks affinity for the cannabinoid receptors CB1 and CB2.

Primary reports also have provided evidence that PEA downregulates hyperactive mast cells in a dose-dependent manner, and that it alleviates pain elicited in mouse models. PEA and related compounds such as anandamide also seem to have synergistic effects in models of pain and analgesia.

Palmitoylethanolamide (PEA), also called palmitoylethanolamine or N-2 hydroxyethyl palmitamide), belongs to the family of N-acylethanolamines (NAEs), naturally occurring, biologically active lipids that feed into the 2-AG pathway of the endocannabinoid system that produces anandamide. Increasing anandamide results in the calming, anxiolytic effect of PEA.

The history of PEA as a natural food ingredient with medicinal properties was first identified in 1943 as part of an epidemiological study focused on childhood rheumatic fever, which was noted to occur more frequently in those children who ate fewer eggs. Subsequently investigators noted that the occurrence of rheumatic fever was reduced in children fed egg yolk powder. Subsequently PEA was first identified in the 1950s as being an active anti-inflammatory agent in chicken egg yolk.

WHAT IS PEA?

All mammals create Palmitoylethanolamide or PEA when they metabolize dietary fats. This normal production of PEA helps regulate your pet’s natural inflammatory and pain response. When consumed as a supplement, extensive studies and clinical trials have indicated that PEA relieves inflammation and pain in a number of mammal species, including humans, canines and rodents. 

Although PEA is self-generating, and all mammals naturally produce it to help address their inflammation and pain, your pet may need more PEA than their body is capable of producing to help manage discomfort.

IS PEA SAFE?

PEA has no known side effects. As a compound that is naturally created in all mammals, PEA has a remarkable safety profile. PEA has been studied for more than 40 years in Europe, where it is sold as a food supplement for humans. Thousands of animal and pet subjects, as well as humans, have consumed PEA in peer-reviewed, published, and controlled research studies. These studies have found PEA to be remarkably well-tolerated and safe.

HOW DOES PEA WORK? 

PEA is produced by an enzyme called fatty acid amide hydrolase (FAAH) during fat metabolism. PEA signals cellular regulators to support a healthy inflammatory and pain response throughout the body, like in the hips, joints and skin of our four-legged companions. In this way, PEA is central to regulating a body’s inflammation and pain.

A New Generation of Pain and Inflammation Relief for Dogs

A long history of safety (and dozens of clinical trials) have evaluated the effects of PEA, short for palmitoylethanolamide.

But in 2017, a group of U.S. researchers got together and asked a big question:

"What if we could improve on the effects of PEA?"

Flash forward to January 2020, preliminary data was announced from a landmark study on PCQ Pet™ in older dogs at Texas A&M Veterinary School.

The findings were compelling.

Older dogs taking PCQ Pet™ experienced the following:

1. 58% reduction in pain interference

2. 57% improvement in quality of life

3. 32% reduction in pain severity

   
   

The university findings were considered astonishing by the scientific research team, who stated that the effects were "better than glucosamine". 

After years of research and extensive market trials, the conclusions on the patent-pending formula in PCQ Pet are clear:

• Dogs taking PCQ Pet™ experienced a significant increase in physical activity and exercise.
   
• Dogs taking PCQ Pet™ were more likely to stay active and healthy through their middle age and golden years.

Findings based on clinical and in vitro assays finding synergistic reduction in inflammatory markers, including a pilot clinical study on 7 older dogs with osteoarthritis of hip and knee, conducted at Texas A&M University Veterinary School*.

 
Please visit our Scientific References page to learn more about the powerful research supporting the synergistic ingredients in PCQ Pet.

*Texas A&M University does not endorse any products.